What was the principal scientific discovery that significantly improved the efficacy of psoriasis therapy over the past 25 years? Please explain the discovery, mechanism, and its impact on treatment approaches, focusing on how it changed clinical practices and patient outcomes.

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The principal scientific discovery was the elucidation of the IL-23/Th17 immune axis, with IL-23—specifically via its p19 subunit—as the upstream, non-redundant survival factor for pathogenic Th17 cells, and IL-17 as a key downstream effect…

What was the principal scientific discovery that significantly improved the efficacy of psoriasis therapy over the past 25 years? Please explain the discovery, mechanism, and its impact on treatment approaches, focusing on how it changed clinical practices and patient outcomes.

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