Identify the principal scientific discovery that significantly enhanced the efficacy of psoriasis therapy in the last five years. Include evidence supporting its impact and any key mechanisms involved. Don't be overly scientific.

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The Answer

The principal scientific advances in psoriasis therapy over the last five years are dual IL-17A/F blockade and IL-23p19-selective inhibition, which together represent a co-leadership model: one redefining the ceiling of skin clearance, the…

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The Reasoning

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